SUVN-502 mesylate ( SUVN502 )

产品货号. M12698 CAS No. 1791396-46-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

SUVN-502 mesylate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SUVN-502 (SUVN502)is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.
产品描述

SUVN-502 (SUVN502)is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM; shows high selectivity over 5-HT2A receptor and other 100 target sites; produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus combined with donepezil and memantine; shows potential for treatment of Alzheimer's disease.Alzheimer Disease Phase 2 Clinical
同义词

SUVN502
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

Neurological Disease
适应症

Alzheimer Disease

CAS Number

1791396-46-7
分子量

574.51
分子式

C22H28BrN3O6S2
纯度

>98% (HPLC)
溶解度

——
SMILES

CN1CCN(CC1)CC2=CN(C3=C2C=C(C=C3)OC)S(=O)(=O)C4=CC=CC=C4Br.CS(=O)(=O)O.CS(=O)(=O)O
化学全称

1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole methanesulfonate

1. Nirogi R, et al. J Med Chem. 2017 Mar 9;60(5):1843-1859.
2. Nirogi R, et al. J Pharm Biomed Anal. 2017 Apr 14;145:423-430.

计算器

产品手册

关联产品

Maprotiline hydrochl...

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs).
SB-200646

SB-200646 is a selective and potent?antagonist of 5-HT2B/5-HT2C receptor.
WAY 163909

A highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM.